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lumacaftor/ivacaftor will minimize the extent or effect of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of abemaciclib with strong CYP3A4 inducers decreases plasma concentration of abemaciclib and its metabolites.An overdose of fulvestrant will not be overly probable as its ad